Evaluate compliance with European Medical Device Regulation 2017/745 covering device classification, quality management, clinical evaluation, post-market surveillance, and vigilance
MDR Article 51: Classification rules based on duration, invasiveness, and risk
Article 27: European Database on Medical Devices and Unique Device Identification
Article 27 & Annex VI Part C: UDI-DI on labels, UDI-PI for production identification
Article 10: QMS must address design, manufacture, post-market surveillance
Article 15: PRRC must have expertise in regulatory affairs and QMS
Annex I (3): Risk management throughout device lifecycle
General Safety and Performance Requirements: Design and manufacturing information
Article 10: Complete technical file required for conformity assessment
Annex II: Device description, labels, IFU, specifications, drawings, calculations
Annex II Section 4 & 6: Pre-clinical evaluation and clinical evaluation per Annex XIV
Article 10(4): Documentation must be updated with post-market data and changes
Article 61: CER demonstrating safety and performance through clinical data
Annex XIV Part A: Sufficient clinical evidence from multiple sources
Article 62-80: Clinical investigation requirements, sponsor obligations
Article 61(11): Continuous clinical evaluation with PMCF plan
Article 83: PMS system to proactively collect and analyze data
Article 86: PSURs required at least annually or per notified body schedule
Article 61(11) & Annex XIV Part B: Continuous collection of clinical data
Article 87: Immediate (deaths) or within 15 days (serious injuries)
Article 89: Timely corrective actions and notification to users/patients
Article 88: Trend reporting for potential systematic issues
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