Evaluate medical device risk management per ISO 14971:2019, covering risk analysis, risk evaluation, risk control, and post-production risk monitoring throughout device lifecycle
Clause 4.1: Documented risk management process for all lifecycle phases
Clause 4.4: Plan defines scope, assignments, criteria, review, verification, validation
Clause 4.4(c): Criteria for risk acceptance considering benefit-risk ratio
Clause 4.5: File contains evidence of all risk management activities
Clause 5.3: Characteristics related to safety including normal use and misuse scenarios
Clause 5.4: Use FMEA, FTA, hazard checklists to identify hazards
Clause 5.5: Estimate probability and severity of harm for each hazard
Best practice: Risk matrix visualizes probability vs. severity
Clause 6: Compare estimated risks to acceptance criteria in risk management plan
Clause 6: Risks exceeding criteria require risk reduction measures
Clause 7.1: Hierarchy - 1) Inherently safe design, 2) Protective measures, 3) Information for safety
Clause 7.3: Verification confirms control measures work as intended
Clause 7.4: Risk controls may create new risks requiring analysis
Clause 7.1: Controls embedded in design, protective measures, and user information
Clause 7.5: Verify residual risk is acceptable after risk reduction
Clause 8: Benefit-risk analysis demonstrates benefits outweigh residual risks
Clause 8: Information for safety communicates residual risks to users
Clause 9: Monitor complaints, incidents, field data for emerging risks
Clause 9: Update risk analysis with real-world evidence
Clause 10: Final review confirms completeness and benefit-risk acceptability
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