Assessment for state pharmacy board licensure and DEA controlled substance registration for pharmacies and research facilities
State pharmacy license: Renewal annually or biennially, display certificate, notify board of changes (PIC, location)
PIC: Active pharmacist license, responsible for compliance, sign all reports, must be onsite per state rules
Verify active status: State board lookup, renewal dates tracked, continuing education completed
DEA registration: Form 224 (new), 225 (renewal every 3 years), separate for each location, display certificate
DEA Form 225a: Modification of registration; new DEA number issued for location changes
DEA 222: Triplicate order form for Schedule II; electronic CSOS alternative available with digital certificate
DEA security: CII separate locked storage; CIII-CV dispersed or locked; alarm system for pharmacy
DEA Form 106: Report theft/significant loss to DEA Field Office and state board immediately
Access control: Limited staff with keys/combinations, video surveillance, random audits
Recordkeeping: DEA 222 forms, invoices, prescriptions, inventory records; CII separate from CIII-CV
Biennial inventory: CII exact count, CIII-CV estimated if <1000 units; initial inventory on first day of registration
Perpetual inventory: Track every CII dose received and dispensed; reconcile monthly
USP <797>: ISO Class 7 cleanroom, ISO Class 5 hood, environmental monitoring, garbing; <795>: Beyond-use dating
Compounding documentation: Formula, beyond-use date, lot numbers, pharmacist verification, quality testing
USP <797>: Annual media fill, gloved fingertip sampling, initial/annual competency assessment
Final verification: Pharmacist checks drug, strength, quantity, directions, patient profile, counseling
Patient profile: Demographics, allergies, medical conditions, prescription history, OTC consult
Prescription retention: CII separate, CIII-CV with other records, electronic backups, readily retrievable
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